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Metabolic & Hormonal disorders



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Today's journal articles

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New Clinical Trials

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Previous Journal Entries

Hypoglycaemic episodes in patients with type 2 diabetes - risk factors and associations with patient-reported outcomes: The PANORAMA Study.

An ex vivo potency assay to assess active drug levels of a GLP-1 agonistic peptide during preclinical safety studies.

Telmisartan attenuates hyperglycemia-exacerbated VCAM-1 expression and monocytes adhesion in TNFα-stimulated endothelial cells by inhibiting IKKβ expression.

Novel Regulator of Acylated Ghrelin, CF801, Reduces Weight Gain, Rebound Feeding after a Fast, and Adiposity in Mice.

The Dipeptidyl Peptidases 4, 8, and 9 in Mouse Monocytes and Macrophages: DPP8/9 Inhibition Attenuates M1 Macrophage Activation in Mice.

Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity.

Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development.

Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models.

Discovery and Optimization of Imidazopyridine - based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).

miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7.

Design, synthesis and biological evaluation of novel pyrazolo - pyrimidinones as DPP - IV inhibitors in diabetes.

Clinical efficacy and mechanistic evaluation of aflibercept for proliferative diabetic retinopathy (acronym CLARITY): a multicentre phase IIb randomised active-controlled clinical trial.

Discovery and optimization of novel, selective histone methyltransferase SET7 inhibitors by pharmacophore - and docking - based virtual screening.

Activation of Toll - like Receptor (TLR) 4 Attenuates Adaptive Thermogenesis via Endoplasmic Reticulum Stress.

Clinical potential of vorapaxar in cardiovascular risk reduction in patients with atherosclerosis.

Kinin B1 and B2 receptor deficiency protects against obesity induced by a high-fat diet and improves glucose tolerance in mice.

Immunization of AGE-modified albumin inhibits diabetic nephropathy progression in diabetic mice.

Effects of the Factor Xa Inhibitor, Fondaparinux, on the Stability of Atherosclerotic Lesions in Apolipoprotein E-Deficient Mice.

Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy: A Randomized Clinical Trial.

Empagliflozin as add-on to metformin plus sulphonylurea in patients with type 2 diabetes.

Today's News Items

The Worlds First Smart Insulin Pens with Automatic Wireless Data Transfer (868 MHz or Bluetooth)

Merck Announces U.S. FDA Filing Acceptance of New Drug Application (NDA) for MK-1293, an Investigational Follow-On Biologic Insulin Glargine

BIODELIVERY SCIENCES ANNOUNCES RANDOMIZATION TARGET REACHED IN CLINICAL TRIAL OF CLONIDINE TOPICAL GEL FOR THE TREATMENT OF PAINFUL DIABETIC NEUROPATHY

Shires SHP626 (Volixibat) Receives FDA Fast Track Designation for an Investigational Treatment for Adults who have Nonalcoholic Steatohepatitis (NASH) with Liver Fibrosis

Training Courses & Meetings

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Previous News Items

Millendo Therapeutics Announces Publication of Positive Phase 2a Data for MLE4901 for the Treatment of Polycystic Ovary Syndrome

Amgen And UCB Submit Biologics License Application For Romosozumab To The FDA

Tobira Therapeutics Announces Clinically and Statistically Significant Improvement in Liver Fibrosis From Phase 2b CENTAUR NASH Trial at One Year

​Sanofi Receives FDA Approval of AdlyxinTM for Treatment of Adults with Type 2 Diabetes