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Immunology & Inflammatory Diseases

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Today's journal articles

Crystal structures of human RIP2 kinase catalytic domain complexed with ATP - competitive inhibitors: Foundations for understanding inhibitor selectivity.

Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity.

Do you need further information on any of the agents being evaluated in the trial(s) below?  Let us know...

New Clinical Trials

No clinical trials today

Previous Journal Entries

Collagen-induced arthritis increases inducible nitric oxide synthase not only in aorta but also in the cardiac and renal microcirculation of mice.

Design and synthesis of N - aryl - phthalimides as inhibitors of glucocorticoid - induced TNF receptor - related protein, pro - inflammatory mediators, and cytokines in carrageenan - induced lung inflammation.

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis.

Testing the role of the FcγRIIB immunoreceptor tyrosine-based inhibitory motif in regulation of the B cell immune response.

Enhanced Platelet Toll-like Receptor 2 and 4 Expression in Acute Coronary Syndrome and Stable Angina Pectoris.

Telmisartan attenuates hyperglycemia-exacerbated VCAM-1 expression and monocytes adhesion in TNFα-stimulated endothelial cells by inhibiting IKKβ expression.

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity.

Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPK and PPAR-γ/ROR-γt Signaling.

Association of pentraxin-3 with the severity of rheumatic mitral valve stenosis.

Synthesis, Crystal Structure and Biological Activity Screening of Novel N-(α-Bromoacyl)-α-amino Esters Containing Valyl Moiety.

Interleukin(IL)-36α and IL-36γ Induce Proinflammatory Mediators from Human Colonic Subepithelial Myofibroblasts.

IL-23, Independent of IL-17 and IL-22, Drives Neutrophil Recruitment and Innate Inflammation During Clostridium difficile Colitis in Mice.

Mean Platelet Volume in Crohn's Disease Patients Predicts Sustained Response to a 52-Week Infliximab Therapy: A Pilot Study.

The Dipeptidyl Peptidases 4, 8, and 9 in Mouse Monocytes and Macrophages: DPP8/9 Inhibition Attenuates M1 Macrophage Activation in Mice.

Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-α, IL-β, IL-6 and IL-17A.

Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial.

Stimulation of Central α2 Receptors Attenuates Experimental Necrotizing Pancreatitis.

Higher expression of IL-12Rβ2 is associated with lower risk of relapse in relapsing-remitting multiple sclerosis patients on interferon-β1b therapy during 3-year follow-up.

The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia.

EP4 Receptor-Associated Protein in Macrophages Ameliorates Colitis and Colitis-Associated Tumorigenesis.

Today's News Items

Sun Pharma and Almirall enter into a License Agreement for Tildrakizumab in Europe for Psoriasis

Caladrius Biosciences Receives FDA Fast Track Designation for CLBS03 to Treat Recent Onset Type 1 Diabetes

NICE draft guidance recommends new drug for people with ankylosing spondylitis

Apotex Launches First Generic Version of Merck's Nasonex

GSK in-licenses anti-IL-33R monoclonal antibody for severe asthma from Janssen

RedHill Announces Last Patient Visit in Phase IIa Study with RHB-104 for Multiple Sclerosis

Training Courses & Meetings

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Previous News Items

Sunovion Announces Results of Phase 3 Long-Term Safety Study Showing SUN-101/eFlow (glycopyrrolate) Was Well-Tolerated in People with Moderate-to-Very Severe Chronic Obstructive Pulmonary Disease (COPD)

CHMP Issues Positive Opinion for ORENCIA (abatacept) in the Treatment of Highly Active and Progressive Disease in Adult Patients with Rheumatoid Arthritis not Previously Treated with Methotrexate in the EU

AbbVie and Bristol-Myers Squibb Announce Oncology Clinical Collaboration to Evaluate the Combination of Rova-T plus Opdivo and Opdivo + Yervoy Regimen

Almirall announces a global licensing agreement with Patagonia for congenital ichthyosis

Tobira Therapeutics Announces Clinically and Statistically Significant Improvement in Liver Fibrosis From Phase 2b CENTAUR NASH Trial at One Year

Sun Pharma and Almirall enter into a License Agreement for Tildrakizumab in Europe for Psoriasis

Omeros Corporation Confirms OMS721 Phase 3 Development Plan with European Medicines Agency

Pfizer Announces Positive Top-Line Results from Pivotal Phase 3 Maintenance Trial of Oral XELJANZ (Tofacitinib Citrate) in Ulcerative Colitis